This list of tallest buildings in San Francisco ranks skyscrapers in San Francisco, California by height. The tallest building in San Francisco is currently the Transamerica Pyramid, which rises 853 feet (260 meters) and is currently the 30th-tallest building in the United States.[1] Another famous San Francisco skyscraper is 555 California Street, which is the city's 2nd-tallest building. It is better known to locals as the Bank of America Center.

Many of San Francisco's tallest buildings, particularly its office skyscrapers, were completed in a massive building boom that occurred from the late 1960s until the late 1980s. This boom was dubbed a "Manhattanization wave" by residents of the city, and was met with mixed reaction. There was less building activity from 1989 through 1999 due to the effects of the Loma Prieta Earthquake, but construction of taller buildings gradually began to resume. The city is currently going through a second boom, with 34 buildings over 400 feet (122 m) proposed, approved, or under construction in the city. San Francisco boasts 16 completed skyscrapers that rise at least 500 feet (152 m) in height, with two more under construction. Overall, San Francisco's skyline is ranked (based upon existing and under construction buildings over 500 feet (152 m) tall) second in the Pacific coast region (after Los Angeles) and seventh in the United States, after New York City, Chicago, Miami, Houston, Los Angeles, Dallas, and Atlanta.